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Changes made to classification of some antidepressants

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Donepezil and cilostazol added to the list of of drugs with Known Risk of TdP. Torsemide added to the list of drugs with Conditional Risk of TdP. Atomoxetine added to the list of drugs with Possible Risk of TdP.

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Fosphenytoin removed from two lists, Ciprofloxacin and Fluconazole moved to Known Risk of TdP list, and Propofol added to the list of drugs with Known Risk of TdP.

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Everyone in DC knows that the FDA Commissioner’s job is the most difficult appointed position in government.

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Hydroxychloroquine added and Trimethoprim Sulfamethoxazole moved on lists

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Update for Online Version of My Medicines Forms

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Hydroxyzine and metoclopramide were added to the list of drugs that cause Torsades de Pointes (TdP) under certain clinical conditions. Hydroxyzine (marketed as Atarax®, Vistaril® and many other brand names) is an antihistamine that is used to treat allergies, anxiety and other conditions. It has been added to the list of drugs with Conditional Risk of TdP because it is associated with TdP in patients with conditions such as low serum potassium or magnesium, extremely slow heart rate or concomitant use of drugs known to cause TdP and/or prolong the QT interval. Metoclopramide (marketed as Reglan® and many other brand names) is an anti-emetic that is used to treat nausea, vomiting and other conditions. It has been added to the list of drugs with Conditional Risk of TdP because it is associated with TdP in patients with conditions such as concomitant use of drugs known to cause TdP and/or prolong the QT interval. Hydroxyzine and metoclopramide have also been added to the list of Drugs to be Avoided by Patients with Congenital Long QT Syndrome (CLQTS) if at all possible.

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TUCSON, AZ – CredibleMeds®, the internationally recognized authority on drug safety, has been awarded a three-year contract from the Safe Use Initiative of the U.S. Food and Drug Administration (FDA) to further their mutual goal of promoting and facilitating the safe use of medicines. Several thousand people in the US die each year from taking certain commonly prescribed antibiotics that have heart toxicity, when safer alternatives could be identified. 

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Extended use of Pantoprazole (Protonix®) and risk of low serum magnesium and cardiac arrhythmias.

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